Vesparax is an antipsychotic medicine. It works by changing the actions of chemicals in the brain. Vesparax is used to treat schizophrenia in adults and children who are at least 13 years old. Vesparax is used to treat bipolar disorder in adults and children who are at least 10 years old. Vesparax is also used together with antidepressant medications to treat the major depressive disorder in adults. Extended-release Vesparax is for use only in adults and should not be given to anyone younger than 18 years old. Vesparax may also be used for purposes not listed in this medication guide.
Use Vesparax sustained-release tablets as directed by your doctor. Check the label on the medicine for exact dosing instructions.
Vesparax sustained-release tablets come with an extra patient information sheet called a Medication Guide. Read it carefully. Reread it each time you get Vesparax sustained-release tablets refilled.
Vesparax sustained-release tablets are best taken in the evening. Take it by mouth on an empty stomach or with a light meal.
Swallow Vesparax sustained-release tablets whole. Do not break, crush, or chew before swallowing.
Continue to take Vesparax sustained-release tablets even if you feel well. Do not miss any doses.
Do not suddenly stop taking Vesparax sustained-release tablets without first talking with your doctor. You may have an increased risk of side effects. If you need to stop Vesparax sustained-release tablets, your doctor will gradually lower your dose.
If you miss a dose of Vesparax sustained-release tablets, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once. If you miss taking Vesparax sustained-release tablets for longer than 1 week, contact your doctor before you start to retake it. Your dose may need to be adjusted.
The most commonly reported Adverse Drug Reactions (ADRs) with Vesparax (≥10%) are drowsiness, dizziness, dry mouth, withdrawal (discontinuation) symptoms, elevations in serum triglyceride levels, elevations in total cholesterol (predominantly LDL cholesterol), decreases in HDL cholesterol, weight gain, reduced hemoglobin and extrapyramidal symptoms.
Given the primary central nervous system effects of Vesparax, Vesparax should be used with caution in combination with other centrally acting drugs and alcohol. Cytochrome P450 (CYP) 3A4 is the enzyme that is primarily responsible for the cytochrome P450 mediated metabolism of Vesparax. In an interaction study in healthy volunteers, concomitant administration of Vesparax (dosage of 25 mg) with ketoconazole, a CYP3A4 inhibitor, caused a 5- to 8-fold increase in the AUC of Vesparax.
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